DESCRIPTION:
Triglycerides (neutral fats) are esters of glycerol and fatty acids (typically three different fatty acids). There are exogenous (chylomicrons) and endogenous triglycerides (pre-beta-lipoproteins). Exogenous triglycerides originate from food, while endogenous ones are produced in the liver. An increase in serum triglyceride concentration is called hypertriglyceridemia, which can be of exogenous or endogenous origin.
DETERMINATION:
The method for determining triglycerides is a colorimetric enzymatic method with GPO-POD. The sample for analysis is serum or plasma (EDTA, heparin). Sample stability is five days at 2°C to 8°C.
CLINICAL SIGNIFICANCE:
By determining the concentration of triglycerides in serum, we aim to ascertain whether the patient has an elevated concentration of triglycerides (hypertriglyceridemia) in their blood, specifically in their serum. An elevated serum triglyceride concentration increases blood viscosity and accelerates platelet aggregation. The result of this is reduced blood flow through the vascular system. Furthermore, elevated blood triglyceride concentrations coincide with decreased HDL-cholesterol levels. Patients with ischemic vascular diseases often have elevated serum triglyceride concentrations. 1) Physiological changes in triglyceride concentration: After consuming a fatty meal, a normal increase in serum triglyceride concentration occurs. The highest values are obtained 6 hours after the meal. 2) Pathological changes in triglyceride concentration: A) Elevated triglyceride concentration in cases of: Peripheral artery disease / Glycogen storage disease types I and VI / Down syndrome / Long-term use of oral contraceptives / Essential hyperlipidemia types I, III, IV, and V, lecithin and cholesterol-acyltransferase deficiency in plasma / Hyperparathyroidism / Hyperthyroidism / Lactosuria / Tangier disease (A-alpha-lipoproteinemia) / Chenodeoxycholic acid therapy for dissolving cholesterol gallstones
3.20€