Laboratory test
S 100
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About the test
The proteins designated S100 are a group of regulatory proteins found most abundantly in cells of the central nervous system and in melanoma cells. They are used to assist diagnosis and monitor disease development and treatment success. Although also present in ganglia, they are most often used for diagnosing melanoma, because melanocytes contain large amounts of S100. A positive correlation with disease stage has been found, and serum S100 concentrations also correlate with the number of affected organs, the presence of liver or bone metastases and the response to chemotherapy or immunotherapy. Elevated concentrations in peripheral blood are specific and sensitive for tumour progression
Measurement
The determination method is ECLIA. The sample for analysis is serum only. The sample is stable for 8 hours at 15-25°C, 2 days at 2-8°C, 3 months at -20°C.
Results
Reference interval: less than 0,105 micro g/L.