DESCRIPTION:
As an enzyme involved in glycolysis, LDH is widely distributed in various tissues and organs. The most LDH is in the liver, skeletal muscles, heart muscle, so it belongs to enzymes that are not particularly specific for any organ. The most valuable information is provided by the determination of LDH activity in the serum in heart attacks, liver and blood diseases, and in the diagnosis of malignant diseases.
DETERMINATION:
LDH is determined by the kinetic method according to the IFCC. The sample for analysis is serum or plasma (heparinized). The serum for analysis must not be hemolytic. The stability of the samples is 7 days at 20 to 25°C, 4 days at 2 to 8°C, 6 weeks at -20°C.
CLINICAL SIGNIFICANCE:
Elevated LDH values are found in: hemolytic anemia, pernicious anemia, myeloid leukemia, infectious mononucleosis, acute infectious hepatitis, toxic hepatitis, chronic hepatitis and liver cirrhosis. In liver metastases, high LDH activities are found, which originates from the malignant tissue itself, which is abundant in glycolytic enzymes. In case of a heart attack, LDH activity in the serum begins to rise 8-10 hours after the heart attack, and reaches its maximum activity after 3 to 5 days. After that, in case of an uncomplicated heart attack, the activity begins to decrease and normalizes 8 to 14 days after the heart attack. LDH is not elevated in angina pectoris and angina pectoris, so it helps distinguish myocardial infarction from other heart diseases.
RESULT:
The reference interval depends on gender, age and work method. The reference interval is displayed on each validated result.
3.20€