DESCRIPTION:
Testosterone travels in the blood in free form (approximately 2-3% is free), bound to specific plasma proteins (SHBG), and very weakly bound to non-specific proteins such as albumin. Free testosterone can be determined directly by laboratory methods or indirectly by determining the T/SHBG ratio (free androgen index or FAI). It more accurately reflects the level of bioactive testosterone than determining total serum testosterone alone.
CLINICAL SIGNIFICANCE:
ELEVATED: Elevated values may be found in non-insulin-dependent diabetes, polycystic ovary syndrome, and hirsutism. DECREASED: Decreased free testosterone values may be found in acquired immunodeficiency syndrome, HIV-1 infection, or acute myocardial infarction.
RESULTS:
Reference Values Men: 0.091–0.579 nmol/L Women: 0.003–0.037 nmol/L
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