{"id":28658,"date":"2020-08-28T15:58:20","date_gmt":"2020-08-28T15:58:20","guid":{"rendered":"https:\/\/poliklinika-analiza.hr\/product\/direct-bilirubin-conjugated\/"},"modified":"2026-06-12T23:14:53","modified_gmt":"2026-06-12T23:14:53","slug":"direct-bilirubin-conjugated","status":"publish","type":"product","link":"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/","title":{"rendered":"Direct bilirubin (conjugated)"},"content":{"rendered":"

DESCRIPTION:<\/strong>
\nIn the cells of the liver parenchyma, bilirubin is separated from albumin and conjugated in the endoplasmic reticulum with glucuronic acid. Conjugated bilirubin is also called direct bilirubin.<\/p>\n

DETERMINATION:<\/strong>
\nThe concentration of conjugated bilirubin is determined photometrically with DPD reagent. The sample for analysis is serum or heparinized plasma. The stability of the sample is 3 days at 2\u00b0C \u2013 8\u00b0C in the dark, or 3 months at -20\u00b0C. The sample for analysis must not be lipemic or hemolytic.<\/p>\n

CLINICAL SIGNIFICANCE:<\/strong>
\n1) Physiological changes in the concentration of conjugated bilirubin Bilirubin from the reticuloendothelial system reaches the circulation where it binds to albumin and as such enters the liver sinusoids and from them into the cells of the liver parenchyma. About 300 mmol (18 mg) of bilirubin enters the liver daily. In the smooth endoplasmic reticulum, bilirubin is separated from albumin and conjugated with glucuronic acid into bilirubin-monoglucuronide and bilirubin-diglucuronide. In this way, the insoluble bilirubin changes into the soluble form of bilirubin and is excreted in the bile. The ratio between conjugated and unconjugated bilirubin in healthy people is constant. 2) Pathological changes in the concentration of conjugated bilirubin Type of jaundice – Hemolytic Children, Serum: 42.8-128, Urine: trace, Color of stool: brown Type of jaundice – Hemolytic Adults, Serum: 1.7-10.3, Urine: neg., Color of stool: brown Type of jaundice – Parenchymal Serum: 17.1-256, Urine: 2-4 +, Color of stool: light brown Type of jaundice \u2013 Obstructive Serum: 128-256, Urine: 4+, Stool color: light Type of jaundice \u2013 Normal serum Serum: 0-3.4, Urine: neg., Stool color: brown A) Increased values of conjugated bilirubin concentration in: Acute and subacute liver necrosis \/ Acute pancreatitis \/ Biliary cirrhosis \/ Liver cirrhosis \/ Cytomegalic inclusion disease \/ Dubin-Johnson syndrome \/ Hemolytic disease in newborns (Erythroblastosis fetalis) \/ Hepatolenticular degenerations \/ Jaundice with liver cell damage (newborns) \/ Pancreatic carcinoma \/ Leptospirosis \/ Rotor syndrome \/ Acquired hemolytic anemia (autoimmune) \/ Viral hepatitis<\/p>\n

SIDE EFFECT OF DRUGS:<\/strong> <\/strong>
\nReduced values:<\/strong>
\nmethemalbumin (up to 22%)
\nIncreased values:<\/strong>
\namphotericin B, dextran, phenazopyridine, levodopa (concentration > 60 mg\/L), methotrexate, nitrofurantoin, piroxicam, sulfapyridine, sulfasalazine<\/p>\n

RESULT:<\/strong>
\nThe reference interval depends on gender, age and the method of determination. The reference interval is displayed on each validated result.<\/p>\n","protected":false},"excerpt":{"rendered":"

DESCRIPTION: In the cells of the liver parenchyma, bilirubin is separated from albumin and conjugated in the endoplasmic reticulum with glucuronic acid. Conjugated bilirubin is also called direct bilirubin. DETERMINATION: The concentration of conjugated bilirubin is determined photometrically with DPD reagent. The sample for analysis is serum or heparinized plasma. The stability of the sample […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"product_brand":[],"product_cat":[86],"product_tag":[],"class_list":["post-28658","product","type-product","status-publish","product_cat-tests","first","instock","virtual","purchasable","product-type-simple"],"yoast_head":"\nDirect bilirubin (conjugated) - Poliklinika ANALIZA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Direct bilirubin (conjugated) - Poliklinika ANALIZA\" \/>\n<meta property=\"og:description\" content=\"DESCRIPTION: In the cells of the liver parenchyma, bilirubin is separated from albumin and conjugated in the endoplasmic reticulum with glucuronic acid. Conjugated bilirubin is also called direct bilirubin. DETERMINATION: The concentration of conjugated bilirubin is determined photometrically with DPD reagent. The sample for analysis is serum or heparinized plasma. The stability of the sample […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/\" \/>\n<meta property=\"og:site_name\" content=\"Poliklinika ANALIZA\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-12T23:14:53+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/direct-bilirubin-conjugated\\\/\",\"url\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/direct-bilirubin-conjugated\\\/\",\"name\":\"Direct bilirubin (conjugated) - Poliklinika ANALIZA\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/#website\"},\"datePublished\":\"2020-08-28T15:58:20+00:00\",\"dateModified\":\"2026-06-12T23:14:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/direct-bilirubin-conjugated\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/direct-bilirubin-conjugated\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/direct-bilirubin-conjugated\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Po\u010detna stranica\",\"item\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cjenik\",\"item\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/cjenik-sve-usluge\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Direct bilirubin (conjugated)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/\",\"name\":\"Poliklinika ANALIZA\",\"description\":\"Medicinsko-biokemijski laboratorij ANALIZA\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Direct bilirubin (conjugated) - Poliklinika ANALIZA","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/","og_locale":"en_US","og_type":"article","og_title":"Direct bilirubin (conjugated) - Poliklinika ANALIZA","og_description":"DESCRIPTION: In the cells of the liver parenchyma, bilirubin is separated from albumin and conjugated in the endoplasmic reticulum with glucuronic acid. Conjugated bilirubin is also called direct bilirubin. DETERMINATION: The concentration of conjugated bilirubin is determined photometrically with DPD reagent. The sample for analysis is serum or heparinized plasma. The stability of the sample […]","og_url":"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/","og_site_name":"Poliklinika ANALIZA","article_modified_time":"2026-06-12T23:14:53+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/","url":"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/","name":"Direct bilirubin (conjugated) - Poliklinika ANALIZA","isPartOf":{"@id":"https:\/\/poliklinika-analiza.hr\/en\/#website"},"datePublished":"2020-08-28T15:58:20+00:00","dateModified":"2026-06-12T23:14:53+00:00","breadcrumb":{"@id":"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/poliklinika-analiza.hr\/en\/product\/direct-bilirubin-conjugated\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Po\u010detna stranica","item":"https:\/\/poliklinika-analiza.hr\/en\/"},{"@type":"ListItem","position":2,"name":"Cjenik","item":"https:\/\/poliklinika-analiza.hr\/cjenik-sve-usluge\/"},{"@type":"ListItem","position":3,"name":"Direct bilirubin (conjugated)"}]},{"@type":"WebSite","@id":"https:\/\/poliklinika-analiza.hr\/en\/#website","url":"https:\/\/poliklinika-analiza.hr\/en\/","name":"Poliklinika ANALIZA","description":"Medicinsko-biokemijski laboratorij ANALIZA","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/poliklinika-analiza.hr\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/product\/28658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/product\/28658\/revisions"}],"predecessor-version":[{"id":28771,"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/product\/28658\/revisions\/28771"}],"wp:attachment":[{"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/media?parent=28658"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/product_brand?post=28658"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/product_cat?post=28658"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/poliklinika-analiza.hr\/en\/wp-json\/wp\/v2\/product_tag?post=28658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}