{"id":28270,"date":"2020-08-28T16:36:59","date_gmt":"2020-08-28T16:36:59","guid":{"rendered":"https:\/\/poliklinika-analiza.hr\/product\/cea\/"},"modified":"2026-06-12T23:23:58","modified_gmt":"2026-06-12T23:23:58","slug":"cea","status":"publish","type":"product","link":"https:\/\/poliklinika-analiza.hr\/en\/product\/cea\/","title":{"rendered":"CEA"},"content":{"rendered":"<p><strong>DESCRIPTION:<\/strong> CEA \u2013 Sample Serum, plasma (Li-heparinate, citrate plasma). Blood is collected in a vacuum tube (vacutube) with a red cap without additives or in a vacuum tube containing gel or in a vacuum tube (vacutube) with a green cap (Li-heparinate). The stability of the sample (serum, plasma) is 6 months at -20\u00b0C, 7 days at 4-8\u00b0C and 1 day at 15-25\u00b0C. Carcinoembryonic antigen (CEA) by its structure is a complex glycoprotein with a molecular weight of 20,000, connected to the plasma membrane of tumor cells from where it can be released into the blood. It belongs to the group of oncofetal antigens that are normally secreted during embryonic and fetal development in the gastrointestinal tissue and pancreas as a cell surface antigen from where it is secreted into body fluids. In adults, CEA is found in very low concentrations, but tumors can re-secrete it in larger quantities. Carcinoembryonic antigen (CEA) is not an organ-specific tumor marker, but it is also one of the most well-known and recognized tumor markers. Its determination can be used in various tumors and has the greatest value in colorectal cancer, pancreatic cancer, stomach, breast, liver, medullary thyroid cancer and bronchial cancer. CEA is used: when cancer is suspected, to control treatment, to control the return of the disease after treatment. CEA is most often used to monitor the success of therapy in cancer patients. It is used in patients who have had surgery to see the response to therapy and to see if the disease has come back. In patients with smaller and earlier tumor stages, the CEA concentration is low, while in patients with advanced tumors or tumors that have spread throughout the body, the values \u200b\u200bare high. When the CEA concentration after therapy reaches the reference range, it is considered that the tumor that produced CEA has been removed. If the CEA concentration remains elevated, it is a sign that the tumor has remained or returned. If the cancer has spread throughout the body (metastases), then the concentration of CEA can be found in other body fluids, not only in the blood. <strong>DETERMINATION:<\/strong> <\/strong> Recommended method of the Croatian Chamber of Medical Biochemists: Analyte\/search: Carcinoembryonic antigen (CEA) Sample: Serum Measurement units: micro g\/L CEA &#8211; Determination: ELISA, Electrochemiluminescent immunoassay. <strong>CLINICAL SIGNIFICANCE:<\/strong> Carcinoma cells are happy to produce large amounts of carcinoembrinal antigen (CEA): Its elevated values \u200b\u200bcan also be found in healthy individuals. CEA is used to monitor the treatment of colorectal cancer, especially when the tumor has metastasized outside the colon. Some other diseases can also cause increased secretion of CEA. Usually CEA returns to normal 1-2 months after surgery. Carcinoembryonic antigen (CEA) is also used to control disease recurrence after treatment. Research shows that an increase in CEA levels precedes the clinical signs of disease relapse by several months. For this reason, its determination should be done frequently: at least every three months, and if possible every month or every second. Since the concentration of CEA can be elevated in cancers other than colon, its level can be used to monitor the progression of these diseases and the response to treatment. Although CEA was first recognized in patients with colon cancer, an abnormal level of CEA in the blood is neither specific for colon cancer nor for malignant disease in general. Elevated CEA values \u200b\u200bcan also be found in a number of other cancers including melanoma, lymphoma, pancreatic cancer, stomach, cervix, kidney, thyroid, liver, ovary, lung and breast, but it is most often used in the diagnosis of the colon, especially when it comes to metastatic disease. CEA can also be elevated in non-malignant diseases (in benign conditions), eg hepatitis, cirrhosis, pancreatitis, inflammatory diseases of the gastrointestinal tract and lungs. In benign diseases, the concentration of CEA is usually 0.25 micro g\/L within 10 days, which means that local recurrence has occurred. In metastases, the increase in CEA is &gt;1 micro g\/L within 10 days. 1) Physiological changes in CEA concentration in serum (plasma) 2) Pathological changes in CEA concentration in serum (plasma) A) Increased values \u200b\u200bof CEA concentration in serum (plasma) in: Uterine adnexa, unspecified \/ Acute myeloid leukemia \/ Alcoholism \/ Anal polyp: Rectal polyp \/ Benign brain and CNS neoplasms \/ Biliary liver cirrhosis unspecified \/ Liver diseases; Liver disease \/ Kidney disease \/ Benign neoplasm of the breast \/ Benign neoplasm of the colon, rectum, anus and anal canal \/ Hepatocellular carcinoma; Liver cell carcinoma \/ Hodgkin&#8217;s disease \/ Infection \/ Bile duct stone without inflammation of the bile duct or gallbladder \/ Kidney cancer, malignant neoplasm of the kidney \/ Renal cell carcinoma \/ Carcinoma in situ of the breast \/ Bladder cancer, malignant neoplasm of the bladder \/ Prostate cancer \/ Cancer of the small intestine \/ Cancer of the testis, malignant neoplasm of the testicle (testicle) \/ Cancer of the uterus, malignant neoplasm of the uterus \/ Colorectal cancer \/ Chronic lymphocytic leukemia (CLL) \/ Chronic myeloid leukemia \/ Chronic hepatitis \/ Chronic viral hepatitis C \/ Malignant diseases \/ Malignant neoplasms of the intrahepatic bile ducts \/ Malignancy of unspecified cells (primary, secondary); Tumor metastases; secondary malignant neoplasms \/ Medullary thyroid carcinoma \/ Non-small cell lung cancer \/ Non-Hodgkin&#8217;s lymphoma \/ Pancreatitis \/ Secondary malignant neoplasm of the liver; liver cancer metastases \/ Small lung cell carcinoma (microcellular) \/ Squamous cell carcinoma (squamous, planocellular) \/ Viral hepatitis \/ Malignant neoplasm of the cervix (cervix) \/ Malignant neoplasm of the large intestine (colon), colon cancer (colon) \/ Malignant neoplasm of the breast \/ Malignant neoplasm of the pancreas, pancreatic cancer, pancreatic cancer \/ Malignant neoplasm of the esophagus, carcinoma of the esophagus \/ Malignant neoplasm of the liver, carcinoma of the liver, liver cell cancer \/ Malignant neoplasm of the liver, (metastases) unspecified \/ Malignant neoplasm of the adrenal gland \/ Malignant neoplasm of other and unspecified urinary organs \/ Malignant neoplasm of the ovary (Ovarian cancer) \/ Malignant neoplasm of the thyroid gland \/ Malignant neoplasm of the connective and soft tissue, unspecified (Sarcoma) \/ Malignant neoplasm of the terminal colon (rectum), Rectal cancer \/ Malignant neoplasm of the stomach, gastric cancer, gastric cancer \/ Malignant neoplasm of the female genital organs, unspecified \/ Malignant neoplasm of the gall bladder B) Decreased values of CEA concentration in serum (plasma) at: <strong>RISK FACTORS:<\/strong> Decreased values: Biotin if more than 5 mg is given daily Hemolysis Kidney transplantation (failure and rejection of kidney transplant) In EDTA plasma values as low as 13% Increased values: Alcoholism Obesity Hemodialysis Human anti-mouse antibodies Smoking DRUG EFFECT: <\/strong> <strong>Decreased values: <\/strong> Analytical reduced values: Dipyrone <strong>Increased values:<\/strong> Biologically increased values: Medroxyprogesterone <strong>RESULT:<\/strong> Reference range (depending on method, sex and age): Women and men: less than 4.6 micro g\/L (less than 4.6 ng\/ml) Non-smokers: less than 4.6 micro g\/L (less than 4.6 ng\/ml) Smokers: less than 10 micro g\/L (less than 10 ng\/ml) Conversion factor (Conv \u2013 SI): ng\/mL x 1 = mg\/L Conversion factor (SI \u2013 Conv): mg\/L x 1 = ng\/ml<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DESCRIPTION: CEA \u2013 Sample Serum, plasma (Li-heparinate, citrate plasma). Blood is collected in a vacuum tube (vacutube) with a red cap without additives or in a vacuum tube containing gel or in a vacuum tube (vacutube) with a green cap (Li-heparinate). The stability of the sample (serum, plasma) is 6 months at -20\u00b0C, 7 days [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"product_brand":[],"product_cat":[86],"product_tag":[],"class_list":["post-28270","product","type-product","status-publish","product_cat-tests","first","instock","virtual","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CEA - Poliklinika ANALIZA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/poliklinika-analiza.hr\/en\/product\/cea\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CEA - Poliklinika ANALIZA\" \/>\n<meta property=\"og:description\" content=\"DESCRIPTION: CEA \u2013 Sample Serum, plasma (Li-heparinate, citrate plasma). Blood is collected in a vacuum tube (vacutube) with a red cap without additives or in a vacuum tube containing gel or in a vacuum tube (vacutube) with a green cap (Li-heparinate). 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Blood is collected in a vacuum tube (vacutube) with a red cap without additives or in a vacuum tube containing gel or in a vacuum tube (vacutube) with a green cap (Li-heparinate). 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