{"id":28171,"date":"2020-08-29T14:56:23","date_gmt":"2020-08-29T14:56:23","guid":{"rendered":"https:\/\/poliklinika-analiza.hr\/product\/pth\/"},"modified":"2020-08-29T14:56:23","modified_gmt":"2020-08-29T14:56:23","slug":"pth","status":"publish","type":"product","link":"https:\/\/poliklinika-analiza.hr\/en\/product\/pth\/","title":{"rendered":"PTH"},"content":{"rendered":"<p><strong>DESCRIPTION:<\/strong><br \/>\nPTH is a single-chain peptide hormone with a molecular weight of 9425 daltons and consists of 84 amino acids. The amino acids (1 to 27) of the N-terminal portion of the hormone molecule are responsible for biological activity. The biological half-life of intact PTH is approximately 4 minutes. In vitro stability of PTH is limited. In vivo, PTH is rapidly cleaved in the liver and kidneys into various fragments. Only the N-terminal amino acids 1\u201334 are required for biological activity (receptor binding). C-terminal fragments apparently have no biological role, but circulate longer in plasma than N-terminal fragments. Therefore, a better parameter for assessing parathyroid gland status is the determination of intact PTH molecule. Blood contains a mixture of intact PTH and various fragments. Specific determination of intact PTH is possible using sandwich immunoassay technique in which one antibody acts (binds) on the N-terminal portion of amino acids 1\u201334, while another antibody reacts with the C-terminal portion.         <\/p>\n<p><strong>DETERMINATION:<\/strong><br \/>\nThe determination method is CMIA. The sample is stable for 2 days at 2-8\u00b0C, at -20\u00b0C for 6 months. The sample for analysis is plasma (EDTA only!).  <\/p>\n<p><strong>RESULTS:<\/strong><br \/>\nReference interval: 1.6\u20136.9 mmol\/L<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DESCRIPTION: PTH is a single-chain peptide hormone with a molecular weight of 9425 daltons and consists of 84 amino acids. The amino acids (1 to 27) of the N-terminal portion of the hormone molecule are responsible for biological activity. The biological half-life of intact PTH is approximately 4 minutes. In vitro stability of PTH is [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"product_brand":[],"product_cat":[86],"product_tag":[],"class_list":["post-28171","product","type-product","status-publish","product_cat-tests","first","instock","virtual","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PTH - Poliklinika ANALIZA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/poliklinika-analiza.hr\/en\/product\/pth\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PTH - Poliklinika ANALIZA\" \/>\n<meta property=\"og:description\" content=\"DESCRIPTION: PTH is a single-chain peptide hormone with a molecular weight of 9425 daltons and consists of 84 amino acids. 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In vitro stability of PTH is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/poliklinika-analiza.hr\/en\/product\/pth\/\" \/>\n<meta property=\"og:site_name\" content=\"Poliklinika ANALIZA\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/pth\\\/\",\"url\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/pth\\\/\",\"name\":\"PTH - Poliklinika ANALIZA\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/#website\"},\"datePublished\":\"2020-08-29T14:56:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/pth\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/pth\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/product\\\/pth\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Po\u010detna stranica\",\"item\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cjenik\",\"item\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/cjenik-sve-usluge\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"PTH\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/\",\"name\":\"Poliklinika ANALIZA\",\"description\":\"Medicinsko-biokemijski laboratorij ANALIZA\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/poliklinika-analiza.hr\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PTH - Poliklinika ANALIZA","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/poliklinika-analiza.hr\/en\/product\/pth\/","og_locale":"en_US","og_type":"article","og_title":"PTH - Poliklinika ANALIZA","og_description":"DESCRIPTION: PTH is a single-chain peptide hormone with a molecular weight of 9425 daltons and consists of 84 amino acids. The amino acids (1 to 27) of the N-terminal portion of the hormone molecule are responsible for biological activity. The biological half-life of intact PTH is approximately 4 minutes. 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