{"id":28130,"date":"2020-08-29T16:11:31","date_gmt":"2020-08-29T16:11:31","guid":{"rendered":"https:\/\/poliklinika-analiza.hr\/product\/urea\/"},"modified":"2020-08-29T16:11:31","modified_gmt":"2020-08-29T16:11:31","slug":"urea","status":"publish","type":"product","link":"https:\/\/poliklinika-analiza.hr\/en\/product\/urea\/","title":{"rendered":"Urea"},"content":{"rendered":"

DESCRIPTION:<\/strong>
\nUrea is the main metabolic product of nitrogenous substances in our body. It is formed from ammonia and CO2 in the Krebs-Henseleit cycle in the liver. It is freely filtered through the glomeruli, and 40-50% of urea is passively reabsorbed in the proximal tubules. The molecular weight of urea is 60 daltons. There are 2 nitrogen atoms in the urea molecule, accounting for 28, so the urea to nitrogen ratio is 2.14 (60\/28). <\/p>\n

DETERMINATION:<\/strong>
\nThe method for urea determination is a kinetic UV method. The sample for analysis is serum, plasma (heparin), or urine. Sample stability is 5 days at 2\u00b0C to 8\u00b0C. <\/p>\n

CLINICAL SIGNIFICANCE:<\/strong>
\n1) Physiological changes in urea concentration. Urea concentration depends on diet. Individuals consuming a high-protein diet have a slightly higher serum urea concentration than those on a low-protein diet. Urea is normally lower in children and women due to less muscle mass compared to adult men. A) Increased values: In normal individuals, blood urea concentration increases with higher protein intake \/ Urea concentration increases with age \/ In late pregnancy due to increased protein intake. B) Decreased values: Blood urea concentration is lower in growing children than in adults \/ In the early stage of normal pregnancy \/ In individuals on a low-protein, high-carbohydrate diet. 2) Pathological changes in urea concentration. A) Increased urea concentration in cases of: Excessive urea production \/ High-protein food intake 12 hours before blood collection \/ Increased catabolism of body proteins \/ Incomplete excretion of urea from the body \/ Renal insufficiency \/ Postrenal insufficiency \/ Prerenal insufficiency \/ Acute pancreatitis \/ Acute post-streptococcal glomerulonephritis \/ Acute kidney failure \/ Atherosclerosis \/ Benign prostatic hypertrophy \/ Heavy chain disease (gamma) \/ Liver cirrhosis \/ Cystinosis \/ Diabetes mellitus \/ Gout \/ Glomerulonephritis \/ Goodpasture’s syndrome \/ Hydronephrosis \/ Hyperthyroidism \/ IgA nephropathy \/ Intestinal obstruction \/ Bladder carcinoma \/ Cholera \/ Congestive heart failure \/ Chronic lymphocytic leukemia \/ Chronic kidney failure \/ Chronic pyelonephritis \/ Leptospirosis \/ Medullary cystic disease \/ Membranoproliferative glomerulonephritis \/ Multiple myeloma \/ Nephrotic syndrome \/ Non-Hodgkin’s lymphoma \/ Polycystic kidney disease \/ Vomiting \/ Pre-eclampsia \/ Septicemia \/ SLE \/ Acquired hemolytic anemia (autoimmune) \/ Shock \/ Lead poisoning \/ Urethritis \/ Liver failure. B) Decreased urea concentration in cases of: Acromegaly \/ Acute and subacute liver necrosis \/ Liver disease \/ Celiac disease \/ Liver cirrhosis \/ Cystic fibrosis \/ Eclampsia \/ Hepatolenticular degeneration \/ Laennec’s or alcoholic cirrhosis \/ After hemodialysis \/ After glucose infusion \/ Nephrotic syndrome \/ Pre-eclampsia \/ Protein malnutrition \/ Toxic hepatitis \/ Liver failure. <\/p>\n

RISK FACTORS:<\/strong>
\nDecreased values:<\/strong>
\n\u2013 Diurnal rhythm: morning \u2013 Fasting \u2013 Smoking \u2013 Pregnancy
\nIncreased values<\/strong>:
\n\u2013 Dehydration \u2013 Diurnal rhythm: afternoon \u2013 Season: summer \u2013 Nephrotoxic drugs \u2013 Stress \u2013 Shock \u2013 Physical exertion \u2013 Trauma<\/p>\n

EFFECT OF MEDICATIONS:<\/strong>
\nDecreased values:<\/strong>
\namikacin, ascorbic acid (conc. > 20 mg\/L), cefotaxime, dipyrone, fluorides, caproxamine, chloramphenicol, levodopa, streptomycin
\nIncreased values:<\/strong>
\nacetohexamide, amino acids, aminophenol, aminosalicylic acid, asparagine, citruplexin, cotrimoxazole, dextran, hydantoin derivatives, phenylurea, guanethidine, chloral hydrate, chloramphenicol, sulfonylurea, tetracyclines<\/p>\n

RESULT:<\/strong>
\nThe reference interval depends on sex, age, and the determination method. The reference interval is displayed on every validated report. <\/p>\n","protected":false},"excerpt":{"rendered":"

DESCRIPTION: Urea is the main metabolic product of nitrogenous substances in our body. It is formed from ammonia and CO2 in the Krebs-Henseleit cycle in the liver. It is freely filtered through the glomeruli, and 40-50% of urea is passively reabsorbed in the proximal tubules. The molecular weight of urea is 60 daltons. There are […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"product_brand":[],"product_cat":[86],"product_tag":[],"class_list":["post-28130","product","type-product","status-publish","product_cat-tests","first","instock","virtual","purchasable","product-type-simple"],"yoast_head":"\nUrea - Poliklinika ANALIZA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/poliklinika-analiza.hr\/en\/product\/urea\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Urea - Poliklinika ANALIZA\" \/>\n<meta property=\"og:description\" content=\"DESCRIPTION: Urea is the main metabolic product of nitrogenous substances in our body. It is formed from ammonia and CO2 in the Krebs-Henseleit cycle in the liver. 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